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Transmembrane Technology

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AMR

In the analysis published by The Lancet, 4.95 million people have died in 2019 in association with bacteria AMR. The author estimated that a median of 1.27 million deaths directly attributable to resistance, a value that highly exceeds global HIV deaths (864,000) and malaria deaths(643,000).

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Gram(-) Bacteria

As reported by CDC, more than 2 million cases of antibiotic-resistant bacteria occur every year. It is becoming even more challenging to develop antibiotics that can annihilate multidrug-resistant bacteria. Four types of Gram(-) bacteria among ESKAPE pathogens have outer lipid membrane. Gram(-) bacteria are still resistant

to existing antibiotics, since the outer membrane shuts off the penetration of drugs. MVRIX is developing antibacterial therapeutics for multidrug-resistant bacteria, based on the research of cell membrane translocation mechanism of botulinum neurotoxin.

​슈퍼박테리아 ESKAPE

G(+) Bacteria

G(-) Bacteria

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Enterococcus faecium

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Staphylococcus aureus

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Klebsiella pneumoniae

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Acinetobacter baumannii

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Pseudomonas aeruginosa

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Enterobacter spp.

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Cell Membrane
Translocation

•Delivers antibiotics into periplasm of G(-) bacteria, using cell membrane translocation domain.

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Our Pipelines

MVRIX has two pipelines based on Membrane Translocation Technology.

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